1 TPI - 287 , a New Taxane Family Member , Reduces the Brain Metastatic Colonization of Breast Cancer Cells
نویسندگان
چکیده
Authors’ Affiliations: Women’s Cancer’s Section, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland Bolder Biopath, Inc., Boulder, Colorado Laboratory Animal Sciences Program, Science Applications International Corporation, National Cancer Institute, Frederick, Maryland Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland Quintiles, Inc. Durham, North Carolina
منابع مشابه
Preclinical Development TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells
Brainmetastases of breast andother cancers remain resistant to chemotherapeutic regimens that are effective systemically, in part due to the blood–brain barrier. We report that TPI-287, a new microtubule-stabilizing agent, displays in vitro cytotoxic activity similar to taxanes and epothilones. Unlike the taxanes, TPI-287 is permeable through the blood–brain barrier. Brain-to-plasma ratios of T...
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